Abstract: Fatigue is the main failure mode in pavement engineering. Typically, micro-cracks originate at the bottom of asphalt concrete layer due to horizontal tensile strains. Micro-cracks start to propagate towards the upper layers under repeated loading which can lead to pavement failure. Different methods are usually used to describe fatigue behavior in asphalt materials such as:phenomenological approach, fracture mechanics approach and dissipated energy approach. This paper presents a comparison of fatigue resistances calculated for different dissipated energy models using 2-point bending(2PB) at IFSTTAR in Nantes.2PB tests have been undertaken under different loading and environmental conditions in order to evaluate the properties of the mixtures(stiffness, dissipated energy, fatigue life and healing effect).