Abstract: The emergence of novel infectious diseases has become a serious global problem. Convenient transportation networks lead to rapid mobilization in the context of globalization, which is an important factor underlying the rapid spread of infectious diseases. Transportation systems can cause the transmission of viruses during the epidemic period, but they also support the reopening of economies after the epidemic. Understanding the mechanism of the impact of mobility on the spread of infectious diseases is thus important, as is establishing the risk model of the spread of infectious diseases in transportation networks. In this study, the basic structure and application of various epidemic spread models are reviewed, including mathematical models, statistical models, network-based models, and simulation models. The advantages and limitations of model applications within transportation systems are analyzed, including dynamic characteristics of epidemic transmission and decision supports for management and control. Lastly, research trends and prospects are discussed. It is suggested that there is a need for more in-depth research to examine the mutual feedback mechanism of epidemics and individual behavior, as well as the proposal and evaluation of intervention measures. The findings in this study can help evaluate disease intervention strategies, provide decision supports for transport policy during the epidemic period, and ameliorate the deficiencies of the existing system.